International Journal of Molecular and Cellular Biology

Nickel (Ni) may have influenced on the MMA(V) reductase and DMA(V) reductase activities for inorg-As biotransformation process in humans

Uttam K Chowdhury

Trace elements (As, Se, Zn, Co, Cu, Pb, Cd, Ni, Mn, and Hg) were analyzed in blood of arsenic exposed people in Mexico by using ICP-MS to know the influence of trace elements on the MMA(V) and DMA(V) reductase activities for inorganic arsenic biotransformation process.

The correlations between MMA(V) reductase and DMA(V) reductase activities in blood of both females and males were very weak (F, r= +0.06 and M, r= -0.03, respectively). The activities of MMA(V) and DMA(V) reductase were also not depended on ages of those population (r= -0.05 and r= -0.11, respectively). In this study, there were no significant differences of the MMA(V) reductase and DMA(V) reductase activities in bloods of females and males.

Nickel concentrations in blood were positively and negatively correlated with MMA(V) and DMA(V) reductase activities in blood of both females and males, respectively. These correlations were statistically significant for females. In conclusion of this study suggest that Ni may have influenced for biotransformation process of inorganic arsenic (inorg-As) in humans and itcould enhance arsenic methylation, decrease urinary MMA, and increase urinary DMA.

Abbreviation: SAM, S-adenosyl-L-methionine; SAHC, S-adenosyl-L-homocysteine

Young generation is a boat for carrying and distributing the knowledge of science, health, and everything: How might they grow up?

Uttam K Chowdhury, Shreya Chowdhury

The young generation is a driving force for family, society, nation, and the world. Bangladesh has a young population with ~34% that are aged 15 and younger. Globally, about 25 percent of the world is under 15 years of age, and the total world population estimated by the United Nations has exceeded eight billion in mid-November 2022.These huge numbers of the young generation must grow up properly.

UNCTrust organized two events (“Health Camp” and “Science Fair” in May 2022) in the villages of RamshilUnion under Kotalipara, Gopalganj, Bangladesh.It was remarkable that everyone, mainly the young generation, participated and completed their work according to the instructions,nicely.

Two hundred fifty-three people (166 females and 87 males) got their treatment, from ages 2 to 90 years old, under the UNCTrust Health Camp program. There were four groups based on their ages: I. Pediatric Group, PG (> 0 to 14 years); II. Young Group, YG (15 to 47 years); III. Middle Age Group, MAG (48 to 63 years); and IV. Elderly Group, EG (?64 years) people. The major health problems of the participants in this program are asthma, blood pressure, and heart problems.The Pediatric Group was mainly suffering from asthma, in PG, 20% females but 64% males; YG, 57% females and 54% males; MAG, 50% females and 67% males; andEG, 14.81% females and 67% males are suffering due to asthma.Including all groups, the males are suffering more than the females with asthma.Specially, the males of the pediatric and elderly groups are suffering significantly more than the females of the same age group with this disease. But the females are suffering more than males with blood pressure.The elderly group (EG; specially females) has a significantly higher percentage (11%) of diabetic patients compared to the other age groups.

Almost 100% participants were vaccinated except pediatric group (PG). Most of the participants from YG, MAG, and EG received both doses 1 & 2. Males received more booster doses compared to the females of the same age group (24% vs 9%, respectively) in YG, but females received more booster doses compared to males of the same age group (36% vs. 20%, respectively) in MAG. The 73% of females and 81% of males of elderly group (EG) participants received doses 1 & 2, but 27% of females and 19% of males received booster doses. That means, more percent of females received booster doses compared to males in both MAG and EG.